Research: DEFINE

Determining the Effectiveness of a FeNO-guided asthma management INtervEntion in primary care (DEFINE) is a research study conducted by the University of Oxford.

Its aim is to help health care professionals in GP surgeries provide a more personalised approach to managing patients’ asthma by using FeNO to guide decisions about their treatment.

FeNO stands for Fractional Exhaled Nitric Oxide and is measured using a simple breath test.


Nitric oxide is a gas which everyone breathes out. People with inflamed airways breathe out more nitric oxide than people whose airways are not inflamed. These patients are more likely to have an asthma attack if their inflammation remains untreated.

FeNO is already measured in patients with severe asthma who are seen in hospital clinics. However, very few GP surgeries routinely use FeNO to help them monitor treatment.


A copy of the FeNO Patient Booklet can be found below:



If you or your child would like to take part in this research project and have received an invite, please see the Research Information Sheets below for more information:

  • Adult (16 years or older)

  • Child (12 to 15 years old)


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Research: DEFINE (Personal Details)

If you have received an invite and would like to take part in this research study, please let us know via submitting the form below

If your symptoms are deteriorating or you are having any concerns please make an appointment with our Nurse


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Research: DEFINE (Additional Questions)

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This page was last updated: April 2023